Ib Flavonoid Citrus, Nobiletin, Suppresses ntau lawm thiab cov noob ntawm Matrix Metalloproteinase 9/Gelatinase B hauv luav Synovial Fibroblasts

6 flavonoids cais los ntawm Citrus depressa Rutaceae xws li tangeretin, 6-demethoxytangeretin, nobiletin, 5-demethylnobiletin, 6-demethoxynobiletin, thiab sinensetin suppressed interleukin 1 (IL-1) vim raug yuam zus tau tej cov proMMP-9/progelatinase B hauv luav synovial hlwb ib koob ho txhaj me-yam; nobiletin zoo tshaj plaws suppressed proMMP-9 ntau lawm nrog rau cov thawj hauv nws cov mRNA. Nobiletin kuj txo vim raug yuam IL-1 PGE2 nyob rau hauv lub hlwb synovial ntau lawm, tiam sis ho tsis hloov lub synthesis tag nrho cov protein. Cov teebmeem ntawm tus nobiletin suppressive tau cai hauv luav articular chondrocytes. Nobiletin inhibited proliferation ntawm luav synovial fibroblasts nyob hauv txoj kev loj hlob theem.

Qhov luag kuaj kom muab nobiletin yog lub tshiab antiinflammatory tus neeg sib tw uas muaj rau inhibit PGE2 ntau lawm, matrix degradation pob txha mos articular, thiab pannus uas muaj nyob rau hauv osteoarthritis thiab rheumatoid mob caj dab.