Apigenin Flavonoid kev pab thiab kev tshawb kawm siv Cancer thiab kab

Apigenin nyob rau hauv siab lawm nyob rau hauv ntau cov tshuaj xws li zaub txhwb qaib, thyme, thiab peppermint. Nws kuj muaj nyob rau hauv ntau lwm yam tshuaj, xws li chamomile tshuaj ntsuab, Horsetail tshuaj ntsuab, tshuaj tauj tshuaj ntsuab, perilla tshuaj ntsuab, tshuaj ntsuab vervain thiab yarrow. Caw liab thiab soob ntses muaj flavonoid no, ib yam nkaus thiab.


Thaum muaj ntau yam flavonoids, nws tau rau lwm tus kom tsis txhob mob vim nws muaj txoj kev los tiv thaiv tus mob. Apigenin kuj yuav raug tus mob no pab tau thaum nyob hauv koob tshuaj tiv thaiv mob vim nws yeej sau zog.


Apigenin thiab cov yam ntxwv analogues chrysin thiab luteolin yog siv los ntsuam xyuas nws lub peev xwm los inhibit zus tau tej cov pro-inflammatory cytokines lipopolysaccharide (LPS)-stimulated neeg peripheral ntshav mononuclear hlwb (PBMC). Tas, flowcytometric tsom xam twb tau piv tau qhov teebmeem apigenin, chrysin, luteolin, quercetin thiab naringenin rau ntawm tes ntau yam nyob rau hauv PBMC. LPS-stimulated PBMC tau coj mus kuaj xwb nyob ib puag ncig ntawm flavonoids thiab TNFalpha, IL 1beta thiab IL-6 tau li hauv lub supernatants. Nyob mus tib seem, metabolic txav ntawm tus PBMC yog muab raws xab kev ua npe lus hu ua succinate. Apigenin, chrysin thiab luteolin koob-dependently inhibited cytokine pro-inflammatory ntau lawm thiab metabolic txav ntawm LPS-stimulated PBMC. Nrog ua concentration apigenin, chrysin los yog luteolin monocytes/macrophages zoo thaum uas ntsuas los ntawm flowcytometry. Qhov no kuj nyob rau hauv cov PBMC uas muaj cov-LPS-stimulated tus. Tib lub sijhawm muaj kev nce rau hauv lub hlwb tuag heev. T - thiab B-lymphocytes yeej tsis cuam tshuam dab tsi. Quercetin thiab naringenin tau zoo tsis muaj teebmeem cytokines, kev ua metabolic los yog rau cov hlwb nyob qhov tshawb nrhiav ntawm tes. Conclusion, monocytes twb yeej eliminated nyob PBMC los ntawm apigenin, chrysin los yog luteolin kho nyob rau hauv vitro thaum uas tsis muaj ntau (microM ntawm 8), nyob twg apigenin tshum sim rau tau lub tshaj hwj chim.


Lub flavones luteolin and apigenin inhibit hauv vitro antigen kev proliferation thiab interferon-gamma ntau lawm los murine thiab neeg autoimmune T hlwb.