Yog cov tshuaj lutein zoo

Luteolin yog rab koob kub daj uas muaj cov dej siv lead ua sib cais los ntawm ethanol. Soluble hauv ethanol, ether; me ntsis soluble hauv dej kub, nyuaj rau yaj hauv dej txias. Cov tshuaj tov aqueous yog pleasantly daj, yaj hauv 10% aqueous sodium hydroxide thiab tsaus daj. Ruaj nyob rau cov neeg mob ib txwm muaj.

Pharmacological kev ua si

1. Luteolin muaj ntau yam kev ua tshuaj, thiab cov nroj tsuag nplua nuj nyob hauv luteolin feem ntau yog siv los ua cov tshuaj hauv Suav los kho kab mob. Nrog cov kev tshawb fawb tob ntawm luteolin, nws tau pom tias muaj cov kabmob los tiv thaiv qog xws li tiv thaiv cov qog ua kom lub hlwb loj tuaj, ua rau cov qog cell apoptosis thiab ua kom lub hlwb anticancer ua si, thiab tseem muaj anti-inflammatory, anti-oxidation thiab tiv thaiv rau cov leeg hlwb. Cov. nyhuv.

2. Luteolin yog PDE4 inhibitor, phosphodiesterase inhibitor 2 thiab interleukin 6 inhibitor 3. Nws thim rov qab xylazine / ketamine-inest ua kom tsis nco qab nyob hauv nas. 4 cov kev tshawb fawb pom tau hais tias luteolin tuaj yeem muaj cov teebmeem pharmacological, suav nrog kev tiv thaiv kabmob, tiv thaiv kabmob, tiv thaiv kabmob thiab tua cancer. Kev tshawb fawb ua ntej pom tau tias luteolin tuaj yeem tiv thaiv kev mob qog angiogenesis-vim apoptosis, cuam tshuam rau kev loj hlob ntawm cov qog hauv cov qauv tsiaj, txo qis kev loj hlob ntawm cov qog, thiab nce cytotoxicity ntawm qee cov tshuaj anticancer ntawm cov qog hlwb, qhia tias luteolin tej zaum yuav muaj kabmob kheesxaws tshuaj. thiab tshuaj khomob.

3. Lub tshuab ntawm luteolin bioactivity tuaj yeem tswj hwm qib ntawm ROS, inhibit topoisomerase I thiab topoisomerase II, txo qis kev ua haujlwm ntawm NF-κB thiab AP-1 qhov teeb meem hloov pauv, ruaj khov p53 thiab inhibit phosphoinositide 3 - Kev ua haujlwm ntawm kinase, teeb liab kis thiab tus dhia ntawm transcription 3 (STAT3), insulin-zoo li qhov zoo tshaj yuav loj hlob 1 receptor (IGF1R) thiab tib neeg epidermal kev loj hlob tau receptor II.

lutein

Yog cov tshuaj lutein zoo

Pharmacological kev ua ntawm lutein

1. Los tiv thaiv cov qog: Cov nyhuv inhibitory ntawm luteolin ntawm cov qog cell loj hlob yog feem ntau los ntawm inhibiting qhov kev ua si ntawm qee yam kinases hauv lub cell thiab ntes lub voj voog ntawm tes.

2. Antioxidant: Lub zog antioxidant ntawm luteolin yog qhov tseem ceeb tshwm sim hauv nws tus kheej oxidation cov tshuaj tiv thaiv raws li tus neeg sawv cev txo qis, txhim kho kev ua haujlwm ntawm cov kab mob antioxidant ntawm cov kab mob muaj sia.

3. Kev tiv thaiv kev tiv thaiv: kev tiv thaiv kev tiv thaiv ntawm luteolin yog qhov tseem ceeb hauv nws lub peev xwm los txo cov kev ua haujlwm ntawm trans factoral transmissionsal thiab txo cov khoom tsim tawm ntawm cytokines thiab inflammatory mediators.

4. Cov nyhuv neuroprotective: luteolin muaj kev tiv thaiv ntawm kev kawm thiab cim xeeb ntawm lub paj hlwb.

5. Cov tshuaj tiv thaiv fibrosis: luteolin tuaj yeem txo qhov siab ntawm daim siab mob ntshav siab, txo cov ntsiab lus ntawm hydroxyproline (HYP), malondialdehyde (MDA) thiab hom I procollagen mRNA hauv daim siab mob siab, tiv thaiv lub siab lub hnub qub hauv vitro Proliferation thiab collagen synthes ntawm squamous cells ( HSC). Nws tuaj yeem txhim kho histopathological hloov ntawm pulmonary fibrosis ntxias los ntawm bleomycin, txo lub ntsws nyhav index, txo qhov nce ntawm MDA thiab HYP, thiab inhibit qhov qhia kev hloov pauv kev loj hlob-β1 (TGF-β1) mRNA nyob rau hauv cov ntaub so ntswg. Hauv vitro, nws tuaj yeem inhibit qhov loj hlob ntawm tib neeg embryonic lub ntsws fibroblasts thiab txhawb lawv apoptosis.

6. Los tiv thaiv kev muaj tshuaj thiab cov tshuaj hormones: Luteolin muaj cov koob tshuaj tseem ceeb los tiv thaiv kev cog lus. Tom qab lub qhov ncauj tswj hwm, nws muaj peev xwm nce ntxiv qhov hnyav, taub, endometrial tuab thiab qhov siab ntawm epithelial hlwb ntawm lub tsev menyuam. Estrogenic cov teebmeem, tab sis thaum ua ke nrog ethinyl estradiol, qhia tau cov teebmeem antestrogenic.

7. Lwm yam: luteolin tuaj yeem tiv thaiv ntau hom kab mob thiab kab mob, xws li Staphylococcus aureus, Escherichia coli, tus kab mob pob sawv hlwv yooj yim, tus kab mob poliovirus, Coxsackie B3 tus kab mob. Nws inhibits cov kev ua ntawm HIV-1 integrase thiab muaj kev cuam tshuam los tiv thaiv tus kabmob HIV. Luteolin khi rau s2 protein ntawm tus kab mob ua pa nyuaj (SARS) mob coronavirus, li no txwv tsis pub nkag mus ntawm tus kab mob mus rau hauv lub cell host. Luteolin tseem tiv taus Leishmania donovani thiab txwv tsis pub nws txoj kev loj hlob los ntawm inhibiting qhov kev txiav txim ntawm Lewyridarum's topoisomerase I thiab topoisomerase II. Tsis tas li ntawd, luteolin kuj tseem muaj cov tshuaj immunomodulatory.