Apigenin--Antioxidant thiab Chemopreventive

Apigenin yog ib qho antioxidant flavonoid. Muaj zog chemopreventive thiab antitumor. Induces apoptosis. Cheeb qhov uas cov proliferation ntawm malignant mob hlwb los ntawm G2/M ntes. Yog ib daim ntawv qhia-Kinase (MAPK/ERK) inhibitor. Cheeb qhov uas hypoxia-inducible tau-1 (HIF-1) thiab yam ntxwv vascular endothelial kev loj hlob tau (VEGF). Induces gastric so hauv plab nas, yog suppressing Ca2 + influx los ntawm voltage-his calcium uas raws mas. Apigenin yog ib tug inhibitor xim ntawm CK2. Nyob hauv hlwb WEHI 231 inhibition ntawm CK2 los apigenin tsis rau tus nqi uas IκBα turnover thiab nuclear seb NF-κB (20 µM). Nws nplov ntawm Wnt-1 transfected hlwb proliferation thiab abrogates phosphorylation ntawm β-catenin. Nyob hauv nas tshwm glomerulonephritis, inhibition ntawm CK2 los apigenin ameliorates hlaus kawg.