Apigenin Flavonoid kev pab thiab kev tshawb kawm siv Cancer thiab kab mob cancer ntshav los ntawm Sahelian, M.D. txoj sab ci

Apigenin nyob rau hauv siab lawm nyob rau hauv ntau cov tshuaj xws li zaub txhwb qaib, thyme, thiab peppermint. Nws kuj muaj nyob rau hauv ntau lwm yam tshuaj, xws li chamomile tshuaj ntsuab, Horsetail tshuaj ntsuab, tshuaj tauj tshuaj ntsuab, perilla tshuaj ntsuab, tshuaj ntsuab vervain thiab yarrow. Caw liab thiab soob ntses muaj flavonoid no, tseem.

Cov kev pab cuam noj qab haus huv ntawm Apigenin

Thaum muaj ntau yam flavonoids, nws tau rau lwm tus kom tsis txhob mob vim nws muaj txoj kev los tiv thaiv tus mob. Apigenin kuj yuav raug tus mob no pab tau thaum nyob hauv koob tshuaj tiv thaiv mob vim nws yeej sau zog.

Anti-inflammatory

Ibuprofen thiab apigenin induce apoptosis thiab kev mus los ntawm tes ntes nyob rau hauv lub tshuab txais microglia.

Neurosci Lett. xyoo 2005.

Thaum raug mob los yog kab mob, microglia recruited rau daim tawv nqaij ntawm pathology thiab txawj tshuab txais li rawsli kev hloov morphological thiab qhia cov pro-inflammatory cytokines. Puav pheej yuav qhia tias microglia proliferate los ntawm tes faib rau tsim gliosis ntawm daim tawv nqaij pathological tej yam mob xws li cov amyloid plaques nyob tsis nco qab thiab nigra substantia ntawm tus neeg mob Parkinson's disease. Lub hyperactivation ntawm microglia contributes los neurotoxicity. Nyob hauv txoj kev tshawb no tam sim no peb kuaj lub hypothesis tebchaw sau modulate qhov muaj mob ntawm kev mus los ntawm tes thiab induce ntawm lub hlwb activated apoptosis. Peb nug txug cov teebmeem ibuprofen (uas tsis yog-steroidal sau tshuaj) thiab apigenin (ib flavonoid uas sau thiab anti-proliferative zog) rau lub voj ntawm tes rau lub murine microglial ntawm kab BV-2. Qhov nws tshawb pom qhia tias hob apigenin cell to ntes preferentially nyob hauv theem G2/M and ibuprofen los S theem ntes. Qhov ruaj ntawm annexin V-FITC rau lub week ntawm lub hlwb uas ntawd hais txoj apoptotic tau nais maum kuaj, whereas cov DNA ntawd tsuas nrog propidium iodide. Apigenin thiab ibuprofen vim raug yuam apoptosis ho nyob rau theem thaum ntxov thiab lig. Tus induction ntawm apoptosis ibuprofen thiab apigenin yog paub tseeb hais tias siv TUNEL pom, revealing ntawd apigenin thiab ho ibuprofen si apoptosis hauv hlwb BV-2. Soj ntsuam los ntawm txoj kev tshawb no tam sim no hais tias tebchaw sau tej inhibit microglial proliferation los modulating tus ntawm nws muaj mob thiab apoptosis.

Kev nyuaj siab

Zoo li antidepressant los ntawm apigenin thiab 2,4,5-trimethoxycinnamic kua qaub los Perilla frutescens cog nyob hauv txoj kev kuaj no raug tshem tawm ntawm da dej.

Phaw Pharm Biol. xyoo 2003.

Peb kawm los ntawm apigenin thiab 2,4,5-trimethoxycinnamic kua qaub rau nej poob siab kuaj (da dej yuam mus kuaj), thiab hab txhawb noradrenergic, dopaminergic thiab serotonergic cov kev ua ub no rau nas. Kub nyiab thiab biochemical tau qhia nws cov khoom antidepressant uas yuav raug mediated los ntawm cov teebmeem dopamine nas lub paj hlwb.

Khees xawj

Apigenin yog ib tug havzoov khiav flavonoid uas lawm tau hais kom muaj zog los tiv thaiv tus mob thiab yog li poses nyiaj paj tshwj xeeb rau cov kev loj hlob ntawm tus tshiab chemopreventive thiab/los yog chaw tu. tus mob cancer. Tshawb pom peb qhia ib tug tshiab ntawm apigenin nyob rau hauv inhibiting HIF-1 thiab cov VEGF uas yog ib qho tseem ceeb rau lub pob angiogenesis thiab kev loj hlob, paub tshiab signaling molecules uas tsis muaj kev cai no.