Nobiletin, ib Citrus Flavonoid cais los ntawm Tangerines, xyua xim cheeb qhov uas cov hoob kawm A Scavenger Receptor

Peb txoj kev tshawb fawb nais maum kuaj seb puas citrus flavonoids muaj ib tug ntxiv antiatherogenic nyhuv los modulating macrophage metabolism hauv ntawm txoj kev kawm ntawv A scavenger receptor (SR-A) ligand, LDL acetylated (acLDL). Nyob hauv txoj kev tshawb no, acLDL-metabolism hauv thiab SR-A qhia los ntawm kev kuaj quav tib si murine J774A.1 macrophages tug nais maum kuaj tom qab 24 h pretreatment (100 microM) nrog lub flavonoids: naringenin (los ntawm cov txiv kab ntxwv qaub), hesperetin (los ntawm cov txiv kab ntxwv), thiab tangeretin thiab nobiletin (ntawm tangerines).



Ntawm no flavonoids, tsuas nobiletin inhibited (50-72%) acLDL metabolism hauv raws ob cellular roj ester pawg thiab [3H] oleate incorporation rau hauv roj esters. No nobiletin-mediated nyhuv yog ib txog kev SR-A thiab tsis lub ntiaj teb no ntxim rau cov metabolism hauv lipoprotein yog lub macrophage, tag nrho li citrus flavonoids plaub txo cov metabolism hauv ntawm beta-VLDL, uas feem ntau tawm los macrophages ntawm qhov LDL receptor. Cuaj kaum, nobiletin twg tsis muaj feem xyuam rau SR-A protein ntau qhia, raws thaj blot tsom, tsis yog ntawm tes deg qhia ntawm SR-A cuam tshuam dab tsi thaum uas ntsuas los ntawm 4 degrees C ruaj tshawb siv acLDL [125I]. Conclusion, peb tshawb pom hais tias ntxiv rau kom txhob muaj ntshav roj ntau, nobiletin yuav tiv thaiv tau atherosclerosis nyob ntawm phab ntsa vascular ua inhibiting macrophage uas muaj npuas dej ntawm tes.