Citrus Flavonone Hesperetin tiv thaiv hob Letrozole txha nyob ib Mousmodel lub mis.

Aromatase yog ib tug tseem ceeb enzyme hauv tshuaj synthesis, thiab aromatase (contact lenses) (AIs) tau tsim los kho tus mob cancer mis tshuaj-noog. Vim yog cov nondiscriminatory inhibition ntawm cov tshuaj no synthesis, cov neeg AIs kho kuj li. kab mob xws li kab mob nrog tshuaj deficiency, xws li cov pob txha deterioration. Peb kuaj pom tias cov citrus flavonone hesperetin yuav inhibit aromatase, thiab cov tshuaj xim receptor modulator xwm ntawm flavonoid tej dab cov nyhuv undesirable ntawm AIs.

Siab tam sim no, peb yeej ua hauj lwm kev tsim postmenopausal qauv rau mis carcinogenesis los saib kev sis raug zoo tshuaj ntawm hesperetin thiab letrozole, yog ib cov AIs. Nas Athymic nyob ovariectomized thiab transplanted nrog aromatase-overexpressing MCF-7 hlwb (MCF-7aro). Hesperetin raug tswj nyob rau hauv cov zaub mov ntawm 5000 ppm, thiab letrozole yog txhaj sc rau lub txawv koob. Tau tas mas pom tias hesperetin los yog letrozole yuav txo cov qib tshuaj ntshav thiab inhibit loj lub mo. Tseem ceeb tshaj, tsis tau pob txha hob letrozole li thaum uas tus pob txha ntim feem yog lawv los hesperetin tsis muaj compromising rau lub deterrence ntawm cov loj lub mo MCF-7aro. Noj ua ke, txoj kev tshawb no tam sim no pom tias cov hesperetin ntawd yuav yog ib tug neeg cotherapeutic tus kabmob AI.